NIH Solicitations

Neurobiology of Adolescent Drinking in Adulthood (NADIA)(U01 and U24)–The purpose of this initiative is to support a consortium of researchers across different research institutions to clearly define the persistent effects of adolescent alcohol exposure, and to begin to explore the neurobiological mechanisms underlying these effects.This initiative is limited to animal studies only. This FOA will utilize the NIH Cooperative Agreement (U01) or the Resource-Related (U24) award mechanism. NIAAA expects to commit approximately $4 million in total costs in Fiscal Year 2010 to fund one consortium of several new cooperative agreements in response to this RFA. It is anticipated that a single consortium will contain 7-10 individual U01 and U24 applications.  Letters of Intent Receipt Date: January 2, 2010.  Current Closing Date for Applications: Feb 02, 2010    

Request For Applications (RFA) Number: RFA-AA-10-006   

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Transdisciplinary Research in Energetics and Cancer (U54)– Through this FOA, the National Cancer Institute (NCI) solicits applications for the centers for Transdisciplinary Research on Energetics and Cancer (TREC) in nutrition, physical activity, energy balance, obesity, and cancer. The TREC initiative is designed to foster collaboration across multiple disciplines and encompasses projects that cover the biology, genomics, and genetics of energy balance to behavioral, socio-cultural, and environmental influences upon nutrition, physical activity, weight, energetics, and cancer risk. This initiative is open to all qualified candidates regardless of whether or not they participated in the previous issuance of the TREC Program. Applicants responding to this FOA should establish transdisciplinary research teams with the appropriate breadth of expertise. TREC has two main goals, which are: (1) to enhance knowledge of the current mechanisms underlying the association between energy balance and carcinogenesis (from cellular, animal or human models to genetics and genomics and across the cancer continuum from causation and prevention); and (2) to explore and integrate the etiology of obesity behavior and relevant health behavior theories, with broad population impact at the social-environmental and policy levels for prevention and control of obesity. Special focus on children, groups at high risk for obesity, and cancer survivors is encouraged. This FOA will utilize the NIH Cooperative Agreement Specialized Centers (U54) funding mechanism. This FOA is accompanied by a separate limited competition U01 FOA (RFA-CA-10-501), which solicits renewal application for a TREC Coordination Center. For this TREC FOA, the NCI has committed $15M in total costs for FY2010 and $75M in total costs over a 5-year period. Approximately six awards are expected in connection with this FOA.  Letters of Intent Receipt Date: January 26, 2010. Current Closing Date for Applications: Feb 26, 2010    

Funding Opportunity Number: RFA-CA-10-006   

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Seek, Test, and Treat: Addressing HIV in the Criminal Justice System (R01)– This initiative solicits R01 applications to empirically test the seek, test, and treat paradigm in criminal justice populations. The seek, test, and treat model involves reaching out to high risk, hard to reach groups who have not been recently tested (seek), engaging them in HIV testing (test), and initiating, monitoring, and maintaining HAART for those testing positive (treat). Researchers are encouraged to develop, implement, and test strategies to increase HIV testing and the provision of HAART to HIV seropositive individuals involved with the criminal justice system, with particular focus on continuity of HAART during and after community re-entry following incarceration. Key outcome measures include linkage to care (e.g., seen at care center post-release) and viral suppression (e.g., proportion with undetectable viral load 6 months or more after initiation of ART). Applications responsive to this FOA may propose intervention research at the individual, organizational, or system level that leads to effective approaches for expanding access to HIV testing and HAART treatment in the criminal justice system and in community organizations working with criminal justice systems and populations. This FOA will utilize the R01 grant mechanism and encourages multi PI applications and/or multisite studies. The National Institute on Drug Abuse, National Institute of Mental Health, and National Institute of Allergy and Infectious Diseases intend to commit $10.6 million dollars to fund 7 to 9 new awards. Letters of Intent Receipt Date(s): March 2, 2010 Current Closing Date for Applications: Apr 01, 2010   

Funding Opportunity Number: RFA-DA-10-017    

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Prioritizing Molecular Targets for Cancer Prevention with Nutritional Combinations (R01)– This FOA, issued by the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS), of the National Institutes of Health (NIH), invites research applications to enhance our understanding about the dynamic interrelationship that exists between bioactive food components (and/or combinations thereof) and cancer prevention. Although much evidence exists that dietary components are linked to cancer prevention, the interactions among dietary bioactive compounds and food combinations remains under-investigated. Applications are encouraged to consider either multiple dietary bioactive components, intact foods or multiple foods utilizing physiologically relevant concentrations of the agents. New genetic technologies may be employed to study the impact of dietary components on complex cellular and molecular networks, as part of the effort to better understand the basis for the multifaceted interactions of food components with cancer prevention mechanisms. Specifically, applications that apply new high-throughput genomic, epigenomic, proteomic, and metabolomic technologies to prioritize molecular targets of dietary components are highly encouraged. The sites of action that may be evaluated include carcinogen metabolism, DNA repair, cell proliferation, apoptosis, differentiation, hormonal regulation, energetics, inflammation, and/or angiogenesis. In addition, applications should either evaluate multiple molecular targets within a cancer process or multiple processes in order to prioritize which process(es) is/are most involved in bringing about a phenotypic change. It is hoped that advances in this area may assist in optimizing cancer prevention while minimizing potential toxicity due to food components. The resulting information will help define which foods or food components should be considered in isolation or in combination when developing dietary strategies to reduce cancer risk and/or modify tumor behavior. This FOA will utilize the NIH Research Project Grant (R01) award mechanism.  Current Closing Date for Applications: Jan 07, 2013    

Funding Opportunity Number: PA-10-035    

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Epigenetic Approaches in Cancer Epidemiology (R01)– This FOA, issued by the National Cancer Institute (NCI), encourages research applications that propose to evaluate profiles of methylation, histone modifications and micro RNA (miRNA) and their association with risk of developing cancer in different populations. The overarching goal of this FOA is to provide support for population based studies to define the role of epigenetic markers (methylation, histone and micro RNA profiles) changes to understand cancer etiology. This FOA will utilize the research project (R01) grant mechanism, and runs in parallel with a FOA of identical scientific scope, PA-10-032 that encourages applications under the NIH Exploratory/Developmental (R21) grant mechanism. Current Closing Date for Applications: Jan 07, 2013    

Funding Opportunity Number: PA-10-031